Greywolf1: As dtgreene pointed out, there is a huge variety of mods for Oblivion, some of them make the game easier, some harder, some more interesting in whatever sense.
Some make the game better, some worse. Some are really good, while some are horrible and will cause more problems.
The problem, of course, is to figure out which mods fit in which category.
(Also, if you ever run into a technical issue and you are using mods, *please* mention which modes you are using, as it's quite possible that the problem you're having could be caused by a mod or a mod conflict. You generally shouldn't contact GOG or Bethesda about mod-related issues.)
By the way, regarding the DLCs. To my understanding:
* Knights of the Nine can affect certain locations and possibly interfere with some quests. I would recommend leaving this disabled unless and until you actually intend to do that quest.
* The fighter and mage DLCs can interfere with each other in some way, like a certain NPC not being allowed into their home. (Also, note that said DLCs can make things a bit easier, as I believe they each add a merchant with more gold than most, and the mage one I believe gives good deals on stuff.)
* Shivering Isles is a major expansion. It's safe to install it even if you don't intend to play it (unless you're playing an old unpatched version, but the slow resource leak but has apparently been patched), but be prepared for a main quest the size of the main game's main quest, as well as a suitable amount of side quests. (Because of the level scaling, you don't need to be a high level for this expansion, unlike the Morrowind expansions.)