My quick review:
2140: Starts fun, but the campaign missions feels repetitive and often tiresome to complete. Plus the AI always get a free army to attack you when it wants to, make mid-late game frustrating.
2150: The only game I really feel like a commander in a future war. Overall pretty immersive. The difficulty is moderate, the introduction of unit customization is interesting.
2160: Gameplay wise pretty solid, although in some area they add too many things without good balancing (not that previous games have great balancing though). Campaign story feels like B-class movies, instead of a real war, but is fun to play.