Hello.
Did anyone try to run the game by using wine on Linux?

--- EDIT: For the TL:DR reader. Skip this post and read my third post. I figured it out, but do be warned I haven't played the full game yet as of this edit. ----

I gave it a go through GOG Galaxy install and changed the Wine & staging versions from 5.0 and lower. (I haven't tried 5.2, and doubt it would make much of a difference) I even tried it through GameHub to swap around Proton versions, so not using GOG Galaxy. Every attempt lead to a black screen.

Sadly, this game appears to have a lot of problems even for Windows users. Which may be giving issues in Wine/Proton too. =/ There are even people on the Steam forums for this game saying after a few plays the game can't even load their saves anymore.

For the record I used my AMD/AMD system using AMDGPU (non-pro) with both vulkan_radeon and amdvlk for the vulkan on Arch Linux. I will likely be trying this game again on my Intel/Nvidia machine using Arch Linux. Though, I doubt that will make a difference if any. There are not many games where that makes to much of a difference, but I could be surprised I guess. If I manage to get it working on Linux, I'll try to remember to update my post.

I haven't tested it yet on my Intel/Nvidia machine. Though, it will be the proprietary drivers since the open source ones are just not up for task. At least not on my 2080Ti as it was not even that long ago when the Nouveau even added support for my card. That being said, even if it was good it sadly would not even come close to the proprietary drivers in performance. Nouveau, just isn't for gaming, at least if you look at reports even from December 2019 on Phoronix, comparing Nouveau vs Nvidia proprietary.

After trying to launch the game via the same prefix standalone without GOG Galaxy some how GOG Galaxy borked the install of this game. It refuses to even start and freezes GOG Galaxy through Wine, making me have to manually kill off things from a task-manager. (It even freezes GOG Galaxy now trying to verify as it gets stuck at 99% and stops responding. This seems to sometimes happens when trying to run the game installed from Galaxy standalone on a handful of games in Wine. It depends on the game). I've deleted the game on my AMD/AMD machine and am now reinstalling it. I wanted to test some other potential fixes before having to download this game again on my other machine. Which takes a while to do since Devil's Hunt is 22GB in size.

On a side note I got Genesis Alpha One running through GOG Galaxy via Wine today. That game works with a few tweaks, so you don't have to go to it's forum and ask as I already answered that one at least. If interested in that game. :D (Just don't play with a controller, as the game seems to have horrible controller support. Regardless of using xinput or dinput8 controllers via Wine).

Okay, so after doing what I said I would try it works. If you can not tell by my profile I even obtained an achievement on this game now via Linux. :D Achievements are bugged or hidden on this game though so, it says I 100% the game over one of them, lol. gog(dot)com/u/EliteAlien (Edit: It seems the GOG Galaxy client says 100%, but my profile on the website states 3%. Well the game dev might have something to fix, if they even care. Not a big deal to me, but interesting stats being polled wrong in the client).

Anyway, what I did was two things, installed mf-install.sh to the prefix for the game's .exe for "applications" in the wine config. I also set "__GL_SHADER_DISK_CACHE=1" and "__GL_SHADER_DISK_CACHE_PATH=/path-to-prefix/" so it could be helpful for caching shaders. Probably fine without it, but worth mentioning since I did add this globally before installing the Media Foundation workaround. Nonetheless both this game and that one work via my AMD/AMD machine. No doubt the Intel/Nvidia machine will too if the tweaks are set into place.

I can not test that now because I'm setting up a new system. Anyhow, I hope that these workarounds will work w/o the Galaxy client as well.
"Genesis Alpha One" looks (from the gamne trailer) like a shooter for me with some ship-/crew-building.
Please correct me if this is "Mass Effect"-like with a decent story, communication with several NPCs, (side-)quests etc.

It should as neither of those two are required to run GOG Galaxy via Linux. Though you will need to possibly setup potential libraries if not using a version of Proton and you'll likely need d3d stuff if going into it blindly with a fresh go of a prefix. Though, I figured you knew this at least.

Instead of going through the headache of the other methods. I just used GOG Galaxy because it's easier to download and update a game and to use cloud saves. Since I jump between the two machines, I love those cloud saves. I just wish there was a Linux client. =/ Long live Steam for most games until that happens.
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Edit: To answer your edited question.

Genesis Alpha One is kind of a mix of games. You setup your crew in a menu then go into a top down little menu to build your ship. Once you do that you're basically managing your ship in a first person view. You'll travel space scanning areas with the computers in the ship. Then assign crew members to stations, grow crops, get loot, and shoot alien enemies that come into your ship with the cargo. I guess the best thing to compare it with would be FTL, but more graphics and first person. Yet even that isn't the best comparison.