If you are running it under Windows 7, be sure you have read/write/execute permissions to your install folder, or run it in Admin mode.

Create a shortcut with the following Target command line: "C:\Games\One Unit Whole Blood\DOSBOX\dosbox.exe" -conf dosboxBlood_addon.conf -noconsole -c "exit" (Include the quotes). Use the path: "C:\Games\One Unit Whole Blood\" (Again, quotes included) in the "Start In" field of the shortcut properties. Select the gfw_high_addon.ico file in your One Unit Whole Blood folder for the shortcut's icon (Or whatever icon file you wish). You should be good to go without resetting compatibility mode.