Not a clue. Same OS as you, (Win 7 64bit) and similar symptoms but addionally it crashes liberally all over the place as well with an "MFC has stopped responding" error message. (last time it did it when I just tapped ESC to bring up the menu).
Long story short, it seems like Blood 2 is a little flaky at the moment.

you should mention what game you are referring to, but I know it's blood2.
The original cd version has the same problem.
The only fix I know of is running at a medium resolution.
1440 x 900 works.
Also disable multitexturing for image quality.
A3d gives the best 3d sound quality, and works on my x-fi with alchemy installed.
The original blood2 required a hacked AM18.dll to get music working in Vista.
Looks like GOG has gotten that problem fixed, just not hi-res or 32-bit color.

Thanks Entropy.
I'll have to add 1440x900 as a custom res, but I tried 720p and that worked fine. Not really a solution though, as the issue is running it at native res.
Thanks again.

This patch: http://dege.fw.hu/temp/Blood2ResPatch.zip seems to fix all of blood 2s resolution ailments.

Worked for me. :)

Thanks.

Thanks DarknessConcept that worked for me too.