This is more of a note to myself but perhaps will help someone else too:

I just Bought blood 1 for Linux but seems you have to setup sound and graphics yourself if your not on mac or windows. On a hi-res laptop I get a huge black border round the game and no music. The game setup menu doesn't help.

Edit dosbox settings in dosboxBlood.conf

Scale the display:
# set fullresolution to your screen native resolution
fullresolution=2560x1440
output=openglnb


Fix the music
1. sudo aptitude install timidity

2. Add these settings under [midi] - the key names listed in the comments are wrong - use mididevice not device
mpu401=intelligent
mididevice=default
midiconfig=128:0

Bonus: if you get audio sync issues and your using a bluetooth speaker... its because your using a bluetooth speaker. You can adjust the offset in pavucontrol somewhat but its still kinda crappy

...Well that was my playing time for the day gone on fixing this - have lots of funs

The memory thing isn't really an issue. Everything below that seems like there may be some dependencies that DOSBox is looking for but can't find.

Which Linux distribution are you running?

ah. Arch

I'm sure you've found it already but it looks like the Arch wiki has a list of the dependencies required for DOSBox.
alsa-lib, gcc-libs, glu, libgl, libpng, sdl_net, sdl_sound, zlib, gendesk, mesa-libgl

So I go to play blood after I upgrade Ubuntu and mine crashes too with error:
Exit to error: DRC64:Unhandled memory reference

Seems to be related to memory size when using a dynamic core (must use <= 16)

I was able to keep the above settings by replacing vendored dosbox from GOG with newer one from ubuntu:

sudo apt install -y dosbox
cd ~/GOG\ Games/Blood\ One\ Unit\ Whole\ Blood/
mv dosbox dosbox.nouse
mkdir dosbox
ln -s /usr/bin/dosbox dosbox/dosbox

...HTH