Kephin.615: As far as I know, the shadows only have str drain. Not sure if str reaching 0 results in death, I thought that only happened with int.
Any stat reaching zero results in death. For example:
In the unmodded game, stacking Contagion can cause death by stat loss. I actually used this to kill Imoen while still in Irenicus's dungeon. (Her Imoen's Belt prevents her from dying by ordinary means in order to allow her to leave, but this gets around that.)
Apparently, with at least one version of the fixpack, Harper's Call could be used to lower the stats of enemies, killing them that way. (The fixpack developers decided to implement the stat penalties mentioned in the spell description, but didn't think through the consequences, which is probably why the unmodded game doesn't give stat penalties with that particular spell.)
I believe there's a weapon that can permanently lower the attacker's Charaisma, which could drop it to zero. Of course, with the help of temporary Charisma bonuses, it is possible to underflow it and get permanent 25 Charisma. (The Ring of Human Influence helps here.)