mr_daruman: Currently Wiz8 does not run on OSX high sierra unless you go to contents>resources>game>wizardry8> wineskin. set screen options > uncheck Auto Detect GPU.

Now, a nice upgrade I have found:

Go to the Wizardry 8 directory by right clicking "show package contents" (contents>resources>game>wizardry8>drice_c>programfile>Wizardry 8

Open with TextEdit >3DVideo.CFG
Replace Glide2x with OpenGL
set the resolution at 1024 x 768 from the 800x600
set bits at 32 instead of 16. Quite a great graphics improvement, check out the clouds.

Now if you launch the game everything will work except for the cutscenes.
Go back to the Wineskin wrapper (contents>resources>game>wizardry8>Wineskin) set screen options, and check Use mac Driver instead of X11. Uncheck Decorate windows.

Everything should work beautifully and super smooth. In the game I uncheck Mip Mapping, it makes things way to smooth for my taste.
Enjoy!