So, these other messages are from before I purchased Pathfinder. I was able to install it just fine after I purchased it, but the recent update (using GOG Galaxy) resulted in the error about disk access. As a result of restarting GOG to see if adding GOG Galaxy to my "Full Disk Access" rights in my OS Security settings, the prior installation was identified as corrupted and it's currently reinstalling.
As for if this is only for Pathfinder or other games, I have only noticed it on Pathfinder, but...it's the only game I have installed that is currently getting updates--thus, I have no idea if it's specific to Pathfinder or not.
Mac OS 10.14.2, GOG Galaxy 1.2.51(27)
I tried reinstalling from Galaxy while writing this and it refuses install on top of the broken one. Nice! (That's almost certainly a galaxy problem).
Might see if downloading the actual installer and installing it that way works, but, honestly, this game isn't fun due to the sluggishness on my computer, so I may just delete it altogether and try it again once I ditch this 4 year old mac for a shiny new windows computer. It looks like a fun game, but I think Mojave has really butchered performance on this computer. Maybe this would have worked on my machine before I upgraded? Who knows.