I have a Wine prefix with the previous version of Grim Dawn and it works perfectly but, at the time, the game requires some specific Nvidia settings (allow vertical flipping or something like that in Nvidia's settings), it requires Wine Staging for enabling CSMT, and it also requires winetricks and setting a few overrides to native, builtin.

That prefix ran perfectly but I have not yet tested the latest version of the game with the latest version of Wine Staging (1.9.11 as I write this) which has CSMT re-enabled (it was disabled for a couple of versions)