Text adventures are getting short shrift here. Adventure (i.e., Colossal Cave) is an especially surprising omission from a list trying to stress the importance of various adventure games throughout history. And there were many other indisputable classics, such as Planetfall, Suspended, Hitchhiker's Guide, and A Mind Forever Voyaging, along with a host of others almost as good. Zork is a fine series but hardly hints at the diversity and evolution of the genre.
Ironically, text adventures use some of the oldest technology in gaming, yet they age the most gracefully. The best ones will always deserve a look. There were some phenomenal ones coming out regularly a few years back.
Among other things, I'd suggest condensing the individual titles of juggernaut series into single entries on your list. No point debating whether Monkey Island 4 or King's Quest N is more significant than the Enchanter trilogy. You might end up with less than 100 titles, but that's an arbitrary number anyway.
Bioforge had so much combat in it that the expansion was going to feature a gauntlet mode. It's an action-exploration game with some puzzles here and there. Although like most Origin games, it's hard to put in a single genre.
http://www.youtube.com/watch?v=wB0EU2E3LPc http://www.youtube.com/watch?v=jpGFt1XBSBE Outcast is another one that's hard to stick in one category. But it's heavy on exploration, combat, and weapon upgrades. If anything, it's an open-world sim, not a point-and-click adventure. If you're going to list it, you might as well include games like Nocturne and Blair Witch series, along with In Cold Blood, Martian Gothic, and Project Eden.
http://www.youtube.com/watch?v=QLc6bvYh5Cw http://www.youtube.com/watch?v=KmUJJhu7CPM Omikron has combat, but I didn't get far enough to see how integral it is to the game.
Some significant point and click omissions are Chronomaster, Callahan's Crosstime Saloon, I Have No Mouth and I Must Scream, Riddle of Master Lu, and probably most of the stuff in the Lost Adventures of Legend collection (never got around to playing those). Don't overlook Journeyman Project, either. It's a worthy runner up to Myst as a QuickTime-driven first-person adventure.
Ben There, Dan That and Time Gentlemen, Please! are cheap and look primitive. But they're too much in sync with classic adventures to leave out. You could also consider adding Ceville, although I'm not a huge fan of the English conversion. Shadow of the Comet? Definitely. The Star Trek adventures through Final Unity were highly regarded too.
Star Control 2 is arguably a graphic adventure with arcade elements. Like Outcast, it's hard to categorize.
I'm sure there are other adventures I didn't play that should be on this list. Normality, perhaps? There were a lot of well regarded Myst-style games, too, such as Obsidian. Using Myst as shorthand for all the rest leaves out a lot of excellent adventures. Maybe some of these...
http://justadventure.com/yabb/YaBB.pl?num=1046560654 Most of the games you listed are excellent and should be played. You're just overlooking a number that should take precedence over games like Runaway or the more generic entries in Sierra's series. Or Syberia, for that matter.