OK, here's my take, having read all 19 pages (so far!) of this discussion. Apologies in advance for the length of the post, but I haven't seen these issues directly addressed so far.
I bought TW1 on Steam (yeah, boo, hiss, I know! ;) and enjoyed it. I love when a good game is released which is outside the usual misnomered US "AAA" titles. I have purchased several games from smaller publishers and am generally against DRM. I am not as anti-DRM as perhaps I would be in an ideal world. HOWEVER... I bought TW2 from GOG for three reasons: 1) hoping more money would make it's way directly to the studio (and from there, the devs) 2) supporting a reseller (publisher in this case?) not using DRM, as I believe DRM only hinders legitimate buyers, not copyright breakers. 3) The artbook. I like these, but I am not willing to spend that much!
Let me give you three examples of how TW2's DRM affects legitimate buyers.
A) Two years ago, I had no internet at home. I relied on work for downloads. I had to activate (and patch!) a couple of games via my mobile phone. Guess how much fun that was. :( I wouldn't install games on my work PC, though I am a sysadmin. It's part of my security policy, not to mention I don't run Windows at work. This means that patches had to be downloaded and brought home on removable media. This example also works for e.g. students, where they have no internet at home, do on campus, but can't install software. Similar rules apply in workplaces which don't allow access to another boot medium, don't allow access to unauthenticated machines/boot environments, don't allow users to install software, etc. These by no means preclude the downloading of large files (my work link is 100Mbits/s), but they do stop online patches from working.
B) A good friend of mine can't afford internet at home, but has a link at work. He can afford the occasional game. Again, he can't install games at work, so online patching is again out of the question, only offline patches which he can go home and install. OR, he could ask another friend (not me!) to download an illegal copy of some software, or buy a dodgy DVD. The pirate versions contain an installer and cracked patches, or an already-patched version. The dev's get no money from him in this case.
C) Another good friend has a better job and more money, but he lives in the countryside. The only ISP in his area caps usage to 30GB per month. Downloading the full game again (were it even possible in this case) would leave him with not enough bandwidth for much else, including his remote connection to work, BBC iplayer, YouTube and online gaming. Stand-alone patches would either be within his usage cap, or downloadable from me or work and installable from an offline source.
TW2's form of DRM doesn't work for any of these example real-world situations. I appreciate that GOG isn't CDP:RED, so I'm not blaming GOG, but to say their TW2 release is DRM free is disingenuous. It's not a problem for me, but I am morally in the wrong if I ignore problems because they don't directly affect me.
Anyway, hopefully CDP:RED will reverse their stance on the online-only patching, and GOG will be able to either host patches (best option AFAIK), or offer patched versions of the full game for redownloading. As an IT guy, I have to think this last option would be pretty expensive.
PS: A lossless version of the audio would be nice for my non-PC audio system, thanks! :D If I liked the music more, I would be all sadface at not having a top-quality version for my hi-fi, having recently been converted to the joys of decent audio reproduction.