Here Goes -
"She had a face like a saint. . .a Saint Bernard."

Guess no one knows this one. I googled it, and it seems like a Rodney Dangerfied joke.

Wild guess: Under a Killing Moon.

OK - an easier one then:
"Come, we must press on against the tide of naughtiness. Mind your step."

Guess it wasn't so much easier or everyone forgot about this thread.
Anyway, another quote from me as an attempt to revive the thread one more time... or see if it's truly dead now. (As usual, if someone can guess Lou's one, do so.)
It's very easy for those who have played the game in question.
"When you're sad and all alone, cheer yourself with a psycho-clone!"

That's OK; technically, Lou's quote is the one to solve (he was the last correct guesser so far), mine was to bump the topic and give something maybe easier.
So, it's your turn now.
Mine was from Freedom Force, and my favorite villain, Dejá Vu, says it.

My turn? Really? Okay, then...
"So, you're from that flying thing, huh? That thing that looks as big as the Moon, the thing that sometimes passes over our village?"

So, no one has any ideas? Well, then, forget it. Just post another.

Sounds like something from Giantz - Citizen Kabuto?

Nope.

Yeah seems no one knows this one. I'll just pipe in with my googled answer of "UFO: Aftershock" and let someone submit the next quote.

Something new to get the game running:
"I'm from the earth-is-for-softies-fire-is-the-real-deal foundation and we'd like you to sign our charter."

14 days, no replies.
I'll give it a try.
Here goes:
"You're alive!"
"Not for long, I fear."
"Where is Skipper?"
"He just watched as the raiders attacked."
"He went with them to the desert."
"I swear, I will kill all of them."

Made it more easy now, I think.
Okay I'll give a hint:
The game is included in a Humble Indie Bundle.
Let's see if someone knows what I'm talking about.