"My Master is in a foul mood. He will not be pleased..."

Hmmm, it seems we've hit a snag again. I'll post something which I'm sure anyone who has played the game in question will recognize, so that the game can go on.
However, if someone knows Lou's one for sure, please feel free to guess that instead.
"Aha! So how can we speak? We don't have no vocal cords either. Answer that, Mr. Clever!"

Grim Fandango?

No, not that game.

Here's one more from the same dialogue.
"I mean if you think about it, we don't have no muscles or flesh on our bones either... So what keeps us together, sort of thing?"

Oh, thats Divine Divinity.

Correct!
You've gotta love the unique humour in that game ;-).
(For those who haven't played DD yet: here's the whole dialogue.)

Here's one from a newer game.
"Oh great. Excuse me while I projectile vomit."

I certainly don't recognize it (don't think I've played any game with this line in it), but it seems like others don't do either.
Maybe a hint/another quote from the same game?

I'm sorry if this double posts.
Is it Dragon Age: Origins?

I certainly don't remember hearing it but it does sound like something Alistair would say.

Correct Rohan. If you kiss Moragen in front of Alistar while he is in the neutral-hate level, its a dialog.

Don't forget to take your turn! ;-)

Wow, I never was notified. Okay umm...
"Well, I hear that's lucky...Like finding a four-leaf clover."
*Hint: From a console game.
*Hint Hint: It involves a bird crapping on you.