*shrugs*
"Name the Quote". I didn't see anything saying games only.
Fine fine, here goes:
Character 1: Has any people even been hurt in this thing?
Character 2: Of course not! This is the first time, I never tried it on people.

Hmm, day of the tentacle maybe?
From the first post: "The idea is that you say a quote from a game, and someone else guesses what game the quote is from, and who said it"
So it is for games but since I don't think anyone has bothered to guess the character so I think the occasional non-game thing is okay

Well, if these are the rules, then I can't say yea or nay until you give me the characters who said the quote I gave... :P

Hehe hoist by my own petard!
Bernard & Dr Fred?

If you care, you were correct.
Lets stick to game quotes for this game.

Are you sure, it's not between Bernard and Dr. Fred?

I was pretty damn sure I was right so I looked it up on IMDB which agrees with me.
Okay, a long quote from another classic game that should be on GOG but the suits who own the licence haven't seen the light yet
"Ten to one it's the power source for this place. All I need to do now is to find the light switch. Or the plug. Or the fusebox. Or whatever makes this thing work. An instruction manual might help! Maybe a map! And I could use a sandwich. And a hot jukebox and a cold beer!"

Boston Low from The Dig.

Actually it's Hoagie and Dr. Fred... At least that's what the source told me. Oh well.

I got balls of steel.

I believe that's Duke Nukem... in Duke Nukem 3D. Am I correct?

Hells yeah.
Piece of cake

Character 1 : "My wife has been tasting another man's hotdog. Maybe he has the footlong with the special sauce. I want to know whose meatballs have been in her spaghetti."
Character 2 : "You're living in metaphor hell, my friend."
I LOVE THIS GAME!!!

Please don't start just posting random quotes, there is structure to this game to keep it flowing. So for the sake of simpleness please disregard Virama's quote, Prator, it is your turn.