Something about the visuals makes me think of the Alone in the Dark games, and since I've played the first extensively and don't immediately recognize this, I'm just gonna toss out the idea that it might be Alone in the Dark 2.

Nope, but we're in the right time period now.

Makes me think of the walls on Ultima Underworld 2

Nope. What a weird thing to guess. I can't imagine that you'd find something like this in that game...

I have to say I'm shocked that no one's gotten it yet...

Well the picture is 'The Scream'. Is that relevant?

Looks a bit like Ultima Underworld but I dont know why that picture would be in it.

(edit) oops just noticed somebody already said that. In that case I have no idea.

Well, it's relevant in the sense that the game is set after that painting was made...

Phantasmagoria?

Cold. The guesses before were warm.

Doom 2.

I vaguely remember seeing something like that in System Shock

... because that game and its sequel are on GOG :  System Shock  :-)

edit:  Ninja'd !

Fiiiinally :D I was starting to think my choice of game was far too obscure :P Your go. Slaugh gets a gold star on his forehead.

Next one is up :)

KGB by Cryo!